Possibly triggering transphobia in quote below.
Interview here. Money quote below:
Details: You predicted that another episode—about a transgendered character—would make the LGBT community happy. It didn’t.
Seth MacFarlane: That surprised me. I don’t meet a lot of stupid homosexuals. They seem to be a pretty smart bunch. But it seemed that they were not picking up on the fact that it was a very sympathetic portrayal of a transsexual character.
Details: Maybe the fact that Brian barfs his guts out when he realizes he’s had sex with a transsexual threw them off.
Seth MacFarlane: Hey, we’re still Family Guy.We’re not suddenly going to become 7th Heaven. Actually, I guess on 7th Heaven they would probably burn the transsexual at the stake. Let me think of another example. We’re not Mr. Belvedere. Look, Brian happens to be a heterosexual character, as I am. If I found out that I had slept with a transsexual, I might throw up in the same way that a gay guy looks at a vagina and goes, “Oh, my God, that’s disgusting.” It’s just the way we’re biologically wired. They should give that another look.
So see? Seth McFarlane says that transphobic misogynist disgust at trans women is just how guys are biologically wired. Also, anyone who found his comedic tour de force offensive and not funny was a “stupid homosexual.”
So, yeah, I didn’t care much about everyone who said “Oh, you’re being too sensitive, Family Guy is supposed to be offensive” then, and I certainly don’t care now. Seth’s making it pretty clear how he views trans women, and I think that puts a pretty hard limit for his capacity for a sympathetic portrayal. He clearly doesn’t respect the people he’s trying to do a favor to by having a trans character on his shitty show.